Attenuation of Renal Ischemia-Reperfusion Injury by Proanthocyanidin-Rich Extract from Grape Seeds
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چکیده
منابع مشابه
Attenuation of renal ischemia-reperfusion injury by proanthocyanidin-rich extract from grape seeds.
The effects of proanthocyanidin-rich extract in rats subjected to renal ischemia-reperfusion were examined. Proanthocyanidin-rich extract, which is prepared from grape seeds (Vitis vinifera L.), was given orally at doses of 5 and 10 mg/kg body weight/d for 20 consecutive days prior to ischemia-reperfusion. Administration of proanthocyanidin-rich extract attenuated renal dysfunction, as indicate...
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Proanthocyanidins, extracted from grape seeds, are widely used mainly as nutritional supplements. However, there has not been a systematic report to investigate toxicological studies on proanthocyanidins, especially in oral administration. In our studies, proanthocyanidin-rich extract from grape seeds was subjected to a series of toxicological tests to document its safety for use in various foo...
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Chloasma (melasma), an acquired hypermelanosis, is often recalcitrant to various treatments and an amenable, as well as safe, pigment-reducing modality is needed. We investigated that the reducing effect of proanthocyanidin, a powerful antioxidant, on chloasma in a one-year open design study. Proanthocyanidin-rich grape seed extract (GSE) was orally administered to 12 Japanese woman candidates ...
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Introduction: Ischemia/reperfusion (IR) injury involves a complex interrelated sequence of events. High levels of nitric oxide (NO) are generated with inducible form of nitric oxide synthase (iNOS) leading to the renal IR injury and glutathione (GSH) depletion. The present study was designed to investigate the effect of L-Nil (N6- (1-Iminoethyl)-L- lysine.hydrochloride), a selective inhibito...
متن کاملGrape seed protects cholestatic rats liver from ischemia/reperfusion injury.
PURPOSE To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were subjected to 30 min hepatic ischemia, followed by 60 min of reperfusion. Oral administration of 50 mg/kg/d...
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ژورنال
عنوان ژورنال: Journal of Nutritional Science and Vitaminology
سال: 2005
ISSN: 0301-4800,1881-7742
DOI: 10.3177/jnsv.51.283